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frozen dna change

Discussion in 'Dog Discussion' started by Bulldoghistorian, Aug 15, 2021.

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  1. I did not intend to offend anyone when I said dna changes the longer u store sperm
    there about 42 studies out there , when I said sperm was frozen 30 years ago ,I do have proof ,but I can not share so please disregard
    I have no money in these dogs

    please research thawing and dna change please research freezin and dna change

    seriously if u smoke or drink it changes your dna
    FrozenEli likes this.
  2. ben brockton

    ben brockton CH Dog

    Why can't you share?
  3. CopperOFRN

    CopperOFRN Big Dog

    You show me with your electron microscope that alcohol changes my DNA….I’ll be impressed. Or mushrooms,acid, DMT,….man, “wherever you go, there you’ll be”.
  4. FrozenEli

    FrozenEli Premium Member Premium Member

    You didn't offend anyone, I know Old Stupid Goat is stuck in his ways and I also understand you'll are cool. CopperOFRN, I promise all the meth I've smoked has changed mine! Old Goat, where you at you old bitch? let's play
  5. FrozenEli

    FrozenEli Premium Member Premium Member

    I can share and resite all the studies, not just on here.
  6. CopperOFRN

    CopperOFRN Big Dog

    Worst accident I’ve had. .31 after 2 blood transfusions, and a medevacc. Brain bleed, blah blah. 2nd is 95mph into a telephone pole on a cbr600(snapped pole in half) 3rd. F350 into a freight liner(head on) both were totaled. My point is- I was wrecked for the first, and totally sober for the other two. I don’t blame the fire water- I blame the operator
    FrozenEli likes this.
  7. AGK

    AGK Super duper pooper scooper Administrator

    Vicki banned him.
  8. FrozenEli

    FrozenEli Premium Member Premium Member

  9. Vicki

    Vicki Administrator Staff Member

    He should be back today

    All you have to do is Google, there's no big secret.
  10. ben brockton

    ben brockton CH Dog

    This topic is very interesting to me for a few different reasons. Over the past day or so been looking into it. The studies are conflicting with nothing being rock solid on frozen. The only rock solid is that you will lessen the count. Not anything to do with the DNA being charged. If you interpret the fragment change of sperm as DNA changes that is reaching at best. If I take my stock that was raised south of the equator and start a new breeding program in Alaska I ain't going to get Huskies.
    Vicki likes this.
  11. FrozenEli

    FrozenEli Premium Member Premium Member

    Hope he didn't commit suicide after his 2 days in county.
  13. CopperOFRN

    CopperOFRN Big Dog

    Post a link that you deem reputable. I’d like to read it. I just find it hard to believe that alcohol can change your dna. Everything I’ve read says it can affect your genes function but not actually change it. I mean sure- they function differently when I’m all tuned up. They’re drunk. If you think of your body as a gene within the universe it also functions differently while wasted. But sober up and boom- back to functioning normally. It’s like molding a piece of clay. It’s still the same clay- just a fucked up shape. You can thank the THC for this whacky post.
  14. ben brockton

    ben brockton CH Dog

    Did you not read my post? Other than the fragmentation of the sperm which is common sense because it's frozen. What is changing? So you are saying that DNA is morphing? Will the test tube dogs not still have 50% of the DNA passed down from the Male it's collected from? Please post your studies and it will take me 5 minutes to to disprove them with correlating studies.
  15. wicked13

    wicked13 Top Dog

  16. Pullingcovers

    Pullingcovers Big Dog

    DNA of human spermatozoa can be subject to various kinds of modifications acquired throughout life. Put simply, two basic types of acquired sperm DNA modifications can be distinguished: genetic and epigenetic. Genetic modifications cause alterations of the DNA sequence and mainly result from the formation of breakpoints leading to sperm DNA fragmentation. Epigenetic modifications include a vast spectrum of events that influence the expression of different genes without altering their DNA sequence. Both the genetic and the epigenetic modifications of sperm DNA can negatively influence embryonic development, cause miscarriages, and be the origin of different health problems for the offspring. As to sperm DNA fragmentation, reliable diagnostic methods are currently available. On the other hand, the detection of potentially harmful epigenetic modifications in spermatozoa is a much more complicated issue. Different treatment options can be chosen to solve problems associated with sperm DNA fragmentation. Some are relatively simple and noninvasive, based on oral treatments with antioxidants and other agents, depending on the underlying cause. In other cases, the recourse to different micromanipulation-assisted in vitro fertilisation techniques is necessary to select spermatozoa with minimal DNA damage to be injected into oocytes. The treatment of cases with epigenetic DNA modifications is still under investigation. Preliminary data suggest that some of the techniques used in cases of extensive DNA fragmentation can also be of help in those of epigenetic modifications; however, further progress will depend on the availability of more reliable diagnostic methods with which it will be possible to evaluate the effects of different therapeutic interventions.
  17. wicked13

    wicked13 Top Dog

    It's fragments through the freezing and thawing process
    ben brockton likes this.
  18. wicked13

    wicked13 Top Dog

    Using different sperm DNA integrity assays, it has been confirmed that the sperm DNA undergoes structural changes during the freezing-thawing process. Evidence has been shown that a significant proportion of frozen-thawed spermatozoa with compromised chromatin integrity was highly susceptible to DNA fragmentation. Moreover, the possible mechanisms responsible for post-thaw sperm DNA damage could be because of cryo-induced oxidative stress and, to a lesser extent, to the activation of an apoptotic-like phenomenon. This review also highlights the ongoing effort employed to develop optimal strategies to reduce sperm DNA damage following freezing-thawing of boar semen.
  19. ben brockton

    ben brockton CH Dog

    Exactly cold constrict and heat expands so structure integrity is going to be affected. This is why the count drops of viable sperm. Not that the DNA is changing only the structure of some sperm. Yes DNA can and has evolved think the African dogan tribe/ sans people the most genetically diverse group of people on the planet vs nordic people. Lots of factors can change DNA but we talking frozen dog sperm and the DNA remains the same even though structure integrity has been compromise
    Fatman91 and Pullingcovers like this.
  20. Bones1

    Bones1 Big Dog

    david63 likes this.
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