Researchers may have stumbled upon cure for parvovirus

Researchers may have stumbled upon cure for parvovirus

Monday June 2nd, 2014 By DogTime

Canine parvovirus is a devastating diagnosis for any dog. While it cannot spread to humans, it is easily spread from dog to dog, and often the disease quickly turns fatal. While there is a vaccine that can help prevent a dog from contracting the deadly illness, there are still thousands of cases of parvo every year and many dogs that do not survive it.

In shelters, parvovirus is especially challenging. Infected dogs shed the virus through their bodily fluids and waste, making it very easy for the illness to spread from kennel to kennel, from dog to dog. The virus is tough to kill, and can live for months or even sometimes years on surfaces. Puppies and dogs who have not yet been vaccinated are particularly vulnerable to infection.

And what’s frustrating for shelters is the cost of treating the illness; to treat the symptoms of parvo, including fever, bloody diarrhea, vomiting, and dehydration, it can cost between $500 to $2,000 per dose. Often that high cost is insurmountable, meaning infected dogs and puppies either die of the virus or are euthanized.

In many places around the country, cases of canine parvovirus are on the rise. In Los Angeles County, California, for example, officials say the rate of infection is high and on the rise. Between January and April 2014, 162 cases of the virus were logged in the county, and half of those infections sprung up in April alone.

“It’s springtime, you get a lot of newborns during that time and there’s an increase in susceptible hosts,” County of Los Angeles Department of Animal Care and Control head veterinarian Dr. Maria Sabio-Solacito tells the Los Angeles Times. “Out there, once you have a stray dog in the desert you don’t know what can happen.”

But a North Dakota company has stumbled upon a drug that could be a major breakthrough in not only treating canine parvovirus — but actually curing the disease.

Grand Forks, North Dakota, company Avianax was formed after the outbreak of a mysterious illness that was killing large populations of geese across the region. The illness turned out to be West Nile virus. Avianax discovered and developed special antibody technology to fight the disease.

Now, that same technology just might save a lot of puppies. Early tests of the company’s new parvoONE antibody-based treatment, harvested from the yolks of goose eggs, showed a 90 percent cure rate — a potential breakthrough in animal care.

We went to the Mayo Clinic and they looked at all our work,” Avianax Chief Operating Officer Richard Glynn tells the Associated Press. “They called it a game-changing technology.”

“I think there will be a lot of puppy owners who will be very happy,” adds Glynn.

Puppy caretakers at of the eight parvoONE test sites, the Kansas City Pet Project in Kansas City, Missouri, are certainly very happy.

“When the box arrived we were yelling, ‘Woo, the geese antibodies are here!’” Kansas City Pet Project spokesperson Tori Fugate remembers. “Just the fact that someone is caring out there is pretty remarkable. A lot of open admission shelters choose not to treat parvo because it’s considered too much of a resource.”

The Avianax parvoONE trials will continue to run through this November at sites in Missouri, North Dakota, Minnesota, Iowa, Texas, North Carolina, and Arizona. But should the U.S. Department of Agriculture give the go-ahead, Avianax plans to start selling parvoONE for $75 per dose next spring.

parvoONE field trial - YouTube



Researchers may have stumbled upon cure for parvovirus

 

Parvo is a shifting antigen virus, which means it changes configuration over time and with partial cures. Some call it survivor strains. Each new configuration is even stronger when it reconfigures as it is the strongest, most resilient portion of the virus.

This is great news, potentially and I am, of course, happy to hear this, yet with parvo, corona et al being a shifting antigen, my hope is that it kills this villain well enough to curb survivor strains.